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Homo-oligomerization of μ, δ, and κ opioid receptors has been demonstrated, suggesting a critical functional role for receptor receptor interactions.
Our findings suggest a critical functional role of the amino acid residue in position 81 of EF-Tu with respect to aminoacyl-tRNA binding.
From these observations we propose that Mta1 might have critical functional role in orphan nuclear receptor activation, inflammation and infections.
These results demonstrate the critical functional role that the PTE plays in regulating promoter-enhancer interactions at the endogenous Drosophila BX-C.
In addition, the instillation of MCP-1-neutralizing antibodies into mouse lungs blocks cytokine secretion and induces more severe pneumonia, indicating a critical functional role of this particular chemokine.
The bulk of evidence suggests that in human leukemia cells, PEITC-induced Akt inactivation has a critical functional role in mediating PEITC lethality.
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These structure functional analyses suggest that the hydrophilic carboxy-terminal plays critical functional roles in mineralization of enamel and that the lack of this segment causes abnormal mineralization.
In particular, basic residues at positions 355 and 363 of the yeast PriL-CTD, which are strictly conserved among primases and photolyases, have critical functional roles in RNA primer synthesis [8], [11].
Measures of node centrality in biological networks are useful to detect genes with critical functional roles.
Recent progress in the ENCODE and modENCODE projects highlights the critical functional roles of non-coding DNAs in the regulation of biological processes [ 46, 47].
For HIV-1 TAR RNA, base 24 serves mostly as a linker during Tat complex formation, and base 25 has more critical functional roles in Tat recognition.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com