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However, the direct clients of Hsp90 are critical for functioning of many pathways in which an even larger number of proteins are engaged.
The core part of KMC-IMBG1 probably is critical for functioning of the whole community and might be responsible for recovery of the community after disturbance.
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Most of these sequence variants fall in parts of the genome that do not appear to be critical for function.
Finally, the conserved residues in LCD1 could be critical for function.
Sensitive detection of uracil-DNA glycosylase (UDG) activity is critical for function study of UDG and clinical diagnosis.
The reconstruction process can be thought of as a generalized function approximation problem and choice of a proper basis is critical for function approximation.
Hence, knowledge of which proteins in the network lack a particular function is critical for function prediction with diffusion, and may contribute to accuracy advantages over other methods.
The (B2+α2+α3) substructure houses motif IV and its observed flexibility might be important in mediating conformational changes critical for function on interaction with partner proteins.
2. I am not confident that 100% of "invariant" residues are in fact critical for function.
In this case, few residues, which are critical for function, should correspond.
In a closely related set of proteins, even positions that are not critical for function may appear well conserved.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com