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One of critical difficulties of molecular dynamics (MD) simulations in protein structure refinement is that the physics-based energy landscape lacks a middle-range funnel to guide nonnative conformations toward near-native states.
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Behaviorism stumbled upon various critical difficulties with some of its commitments.
However, as-built BIM creation of building interiors using scanned point clouds incurs critical difficulties: the complex design of indoor structures, not to mention obstacles, necessitates time-consuming manual operation and resultantly huge data sizes, which often leads to system slow-down or failure.
Also, critical difficulties associated with utilization of crack closure concept are cross-examined.
Here are some critical difficulties that will challenge any version of driverless car likely to be available in the near future.
Interviews and focus groups broadly covered the following areas: objectives of the CHWs programme, view of the programme's progress in the reality of the districts where it was implemented, positive aspects, critical points and difficulties of the programme (or of the CHWs' work), and perspectives about the continuity or suggestions to improve the programme.
Given the book's fluid and changeable approach to plot and characters, a definitive, critically agreed-upon plot synopsis remains elusive (see Critical response and themes: Difficulties of plot summary below).
Several studies have highlighted the critical importance, and difficulty, of rooting Wolbachia supergroup phylogeny to the solution of this question (Lo et al. 2002, 2007; Fenn et al. 2006; Bordenstein et al. 2009).
However, the interviews were directed towards the intervention rather than a critical investigation of staff dynamics; the difficulties of the latter tended to emerge obliquely and we saw little sign of staff reticence in the discussion of problematic issues.
The technical difficulties of undertaking polysomnography in critical care patients are frequently highlighted [ 1, 27, 36, 37, 46].
But Woolard says it is not reaching many children before their first birthday – when nutritional support is most critical – because of difficulties in accessing birth certificates and identity documents.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com