Sentence examples for critical differentiation factor from inspiring English sources
TGFβ is also a critical differentiation factor for generation of Treg cells [ 78], whereas IL-6, which is expressed in the RA synovium, was shown to inhibit TGFβ-induced generation of FoxP3+ Treg cells [ 49].
Protection of critical differentiation factors from caspase cleavage during this process is therefore necessary, and HSPs have a central role within this context.
RANKL is a critical osteoclast differentiation factor highly expressed on the membranes of the osteoblasts/stromal cells in the bone marrow environment [ 23].
Other important CD4+ T cell-derived stimulatory mediators of osteoclast formation include the critical osteoclast differentiation factor, RANKL [5,8], and the pro-inflammatory cytokine IL-17 [9], which indirectly increases the expression of RANKL on osteoblasts and stromal cells in the local bone microenvironment.
Growth differentiation factor.
myeloid differentiation factor 88. Mycobacterium tuberculosis.
Indeed, TAp63 is capable of inducing growth differentiation factor 15 (GDF15) expression after it has been recruited to the proximal p53/p63 binding site located on the GDF15 promoter and this factor plays a critical role in the regulation of keratinocyte differentiation.
Nrg-1 is a critical growth factor for differentiation of neural precursor cells (NPCs) into myelinating oligodendrocytes.
It is possible that miR-1281 might play a role in adipogenesis as EP300 is a transcriptional co-activator of CCAAT/enhancer binding protein α (C/EBPα) [ 63], which is a critical transcription factor for adipocyte differentiation [ 64].
In the present study, we hypothesized that STAT3, which is the critical transcription factor for the differentiation of Th17 cells, is implicated in IL-17-dependent survival and proliferation of rheumatoid synoviocytes.
Previous detailed studies of WAT differentiation identified peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding proteins (C/EBPs) as critical transcription factors regulating differentiation (reviewed in [17]).
