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In case of hemodynamically relevant stenosis, the combination of various criteria, such as PSV and EDV or ratio of internal to common carotid PSV, is commonly used to define the critical clinical value.
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As a result, while embracing the value of guidelines at a high level, most cardiologists were critical of the actual clinical value of guidelines in their daily practices.
However, the next phase of studies in the field of ctDNA will be critical to define the clinical value of this technology.
Only a few studies failed to do so, thus stimulating a critical discussion on the methodology and clinical value of bone marrow analysis.
I have some critical comments to consider about the theoretical and clinical value of the instrument.
Thus, any genetic biomarker when used in isolation and in absence of critical behavioural or other "environmental" information will have limited clinical value.
Increasing evidence shows that some miRNAs play critical roles in tumorigenesis of CRC and have a potential clinical value in diagnosis, treatment and prognosis evaluation for CRC [ 4- 9].
See related commentary by Weil and Tang, http://ccforum.com/content/15/1/113 The clinical value of circulating lactate has been extensively demonstrated in critical care medicine [ 1].
In the present study, we further demonstrated the expression and clinical value of multiple antigens on a protein level, which should be the critical reason for heterogeneous effectiveness of immunotherapy and provide supportive evidence for 'immunoediting' in human cancers.
Additionally, combining the AUC approach with the 4D-CI extends the smoothing effect across four critical clinical domains and allows for integration of various clinical assessments over time into a single numerical value.
Although VEGF reportedly represents a critical angiogenic factor in the tumor microecosystem, the present study did not suggest that plasma VEGF level has similar clinical value to OPN.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com