Sentence examples for critical cellular functions from inspiring English sources
The tumor suppressor protein that mediates many of these critical cellular functions (p53) is frequently mutated, and has been found to be inactivated or functionally downregulated in breast cancer.
Silencing TDP-43 itself is probably not appropriate, given its critical cellular functions.
RNase L mediates critical cellular functions including antiviral, proapoptotic, antiproliferative and tumor suppressive activities.
Genes with critical cellular functions are frequently regulated through a circuit involving multiple regulatory elements that are brought within physical proximity by DNA folding.
Bacterial lipoproteins (Lpp) compose a large family of surface-exposed proteins that are involved in diverse, but critical, cellular functions spanning from fitness to virulence.
The centrosome is the primary microtubule organizing center of the cells and templates the formation of cilia, thereby operating at a nexus of critical cellular functions.
The small GTPase Rac1 is involved in the regulation of critical cellular functions, such as transcription control, cell cycle, and organization of actin cytoskeleton.
The GABARAPL1 protein is composed of 117 amino acids and is highly conserved throughout evolution, suggesting a critical cellular function.
We observed strong downregulation of pathways for amino acid catabolism (i.e., alanine, aspartate, valine, proline and lysine), suggesting preservation of these amino acids for critical cellular function.
As such, by using the TFs found in S. aureus USA300 as a scaffold to interrogate other sequenced bacterial genomes, we were able to identify: (i) TFs that are conserved in all the bacterial phyla, suggesting an ancient origin and critical cellular function, (ii) those regulators found mainly in the Firmicutes, and (iii) regulators found exclusively in the Staphylococacceae.
They are critical for numerous vital cellular functions and their signaling governs various physiological and pathological processes.
