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There was no significant statistical difference in the usage of antibiotics between patients with severe and critical asthma in the two groups.
It implicated that patients with severe to critical asthma may be more prone to bacterial infection than patients with mild to moderate asthma.
Although there was no significant statistical difference in the rate of antibiotics usage in patients with severe to critical asthma between the two groups, the trend of antibiotics usage in PCT group deceased in comparison with the control group.
Therefore, PCT test prevents antibiotics usage mostly in patients with mild to moderate asthma but without bacterial infection, while most patients with severe to critical asthma do suffer from bacterial infection and need to be treated with proper antibiotics.
Both PCT and IL-6 levels of patients with severe to critical asthma in the PCT group were higher than that of patients with mild to moderate asthma in the same group.
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Other inflammatory parameters that we tested showed no significant difference between patients with mild-moderate asthma and severe-critical asthma.
The patients with severe-critical asthma had higher serum PCT levels and IL-6 levels compared with those with mild-moderate asthma (p < 0.05).
They are mediators of both adaptive and innate immune regulation supporting the theory that a close interplay of adaptive and innate immune regulation is critical in asthma.
Innate lymphoid cells (ILC) could play a critical role in asthma patients as they produce different cytokines associated with asthma.
The university described the study at issue as a baseline physiologic test using an inhaled drug, hexamethonium, to determine how the lung protects the airways from narrowing, a development that plays a critical role in asthma.
"Inspired by our past work using the organ-on-a-chip approach to model the lung alveolus, we created a new microfluidic model of the lung small airway that recapitulates critical features of asthma and COPD with unprecedented fidelity and detail.
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