The arcuate nucleus of the hypothalamus plays a critical role in appetite regulation (see Fig. 1).
The critical impact of appetite stimulation on adherence has already been described in relation to the first theme.
Background: Early life may be a "critical period" when appetite and regulation of energy balance are programmed, with lifelong consequences for obesity risk.
Efforts to delineate the neuronal mediators of leptin action have recently focused on extrahypothalamic populations and have revealed that leptin action within the nucleus of the solitary tract (NTS) is critical for normal appetite and body weight regulation.
There is particular interest in understanding the role of environmental factors in early life, because prenatal and early postnatal life may be "critical periods" when appetite and the long-term regulation of energy balance are permanently programmed with lifelong consequences for risk of excess weight gain (4, 5).
To reverse that trend, Mr. Gates said, "designing to affordability, and not just to desire or appetite, is critical".
It's naïve, though, to suppose that the forces driving the appetite for "critical, incisive" (that is, highly revealing) biographies are all about democracy and demystification.
That Biennale's constituent shows were mostly so-so and/or too-too in the usual way — swamping aesthetic appetite, numbing critical perception — of giant international exhibitions.
Its market debut, set for Friday morning, will be another critical test of investor appetite for technology stocks, ahead of Facebook's multibillion-dollar public offering expected this year.
It may be that this opposition finds its truest expression in the wish that the whole thing would just go away, rather than in an appetite for critical films.
