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And since HIV is missing this critical anchor, it cannot enter its target cells.The good news is that this mutation is quite common, at least among westerners.
The tail was also the critical anchor of the large, powerful hind leg muscles that produced most of the walking force required for moving the many tons of sauropod weight.
Additional experiments using structure-guided mutants show that Nup107 is the critical anchor for Nup133 to the NPC, positioning Nup133 at the periphery of the NPC.
After defining Influenza A/Puerto Rico/8/34 Matrix Protein M1 (H1MP) 40–54 as a DR1201 restricted epitope, the critical anchor residues within this sequence were confirmed by measuring the relative binding of peptides with non-conservative substitutions in competition with biotin labeled H1MP40 54 peptide.
Similar(56)
The Glu66 carboxyl group of SKIP engages in polar contacts to the PPIL1 protein, showing that it is a critical anchoring point of the SKIP peptide.
The eIF3b subunit plays a critical anchoring role within the 5 subunit core of eIF3.
Of the MJ RONs RON2 and 4 have been shown or are believed to be essential, whereas TgRON8 has a critical anchoring function of the MJ to the host cell cytoskeleton but is not essential under the experimental conditions used (Giovannini et al., 2011; Srinivasan et al., 2011; Straub et al., 2011).
Classroom observation often carries a considerable weight in teacher appraisal and improvement systems, and provides the critical formative anchor informing professional development.
Ductile failure is critical for anchor design in seismic applications to avoid brittle catastrophe while existing design codes and guidelines that usually accept steel failure as ductile failure are insufficient, and may overestimate shear capacities and ductility.
As mentioned in our previous study, this carbonyl head on the dihydro-quinolinone ring is critical to anchor the ligand in the active site, which is completely absent in the Pyrabactin structure.
It's a charming book that's half memoir, half critical experiment, anchored in Neyfakh's vague wish to trade in some of his detached self-awareness for his friend's fearless passion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com