Sentence examples for critical alteration from inspiring English sources

Identification of the specific p.Lys66Arg substitution in a significant portion of our pediatric-type follicular lymphoma cohort is highly suggestive of a common and critical alteration, leading to the disease development.

Though the variant 1911G was associated with elevated protein levels in a human kidney cell line expression system [23], the investigation of functional responses to capsaicin, pH and temperature in whole-cell patch-clamp and calcium imaging experiments suggests no critical alteration of receptor structure and function with respect to this receptor variant [24].

In order to determine the optimal therapeutic target for future studies, the question that needs to be resolved is which of EGFR, FGFR2, and NKX2.1 is the most upstream and the critical alteration in primary gastric cancer.

Deiuliis, J. et al. Visceral adipose inflammation in obesity is associated with critical alterations in T regulatory cell numbers.

Comprehensive analysis of cancer genomes has provided important insights in the critical alterations that confer proliferation and survival advantage to the tumor, so-called driver mutations.

Materials from the oral tradition are the stuff of Lopes's literary storytelling: he makes critical alterations as he moves from the romance of the tale to the realism of the novel.

Overall, it is clear that the lack of gross changes in in vivo protein dynamics must obscure critical alterations in specific protein formation, such that combing protein measurements with global transcriptomics provides a powerful solution to understanding the nature of tissue remodelling in multiple organ failure patients.

Colorectal carcinogenesis is associated with critical alterations of the Wnt/β-catenin signalling pathway.

Colorectal carcinogenesis is associated with critical alterations of the Wnt/β-catenin pathway involved in proliferation and survival.

Analyses revealed that the mutation-induced critical alterations of surface electrostatic potential in Cx50 mutants could determine their fate in intracellular trafficking.

A better understanding of the critical alterations implicated in tumor initiation is necessary to reduce the mortality rates through early diagnosis and treatment.