Sentence examples for critical activators of from inspiring English sources

Furthermore, miR-31 was identified as a direct modulator of integrin-α(5) and RhoA, two critical activators of the migratory activity of fibroblasts [ 38].

They are characterized by the presence of a high proportion of IFNγ-producing CD4+ T cells, which are critical activators of microbicidal pathways in bacteria-containing macrophages [2].

Expression of genes encoding glucose-regulated transcription factors in human islets Since PDX1 and MAFA are critical activators of glucose-responsive insulin gene transcription [ 21, 24– 27], we examined the expression pattern of their genes in human and mouse islets.

In addition, PDX1 and MAFA are critical activators of glucose-responsive insulin gene transcription [ 24, 25], with transcription factor abundance and/or activity regulated by glucose in mice [ 21, 26, 27].

To understand the underlying molecular mechanism of Runx2-mediated up-regulation of pAkt in invasive MDA-MB-231 cells, we determined the expression levels of the mTORC2 subunit proteins, which are critical activators of Akt phosphorylation at Serine 473 [ 22, 27].

Therefore although CD103+ intestinal DCs express an abundance of factors involved in TGF-β availability, our data clearly show that αvβ8-mediated TGF-β activation is the critical activator of TGF-β responsible for enhanced Treg induction in the intestine.

Certain Abd1 temperature-sensitive mutants cause a severe growth defect at the restrictive temperature, and a screen for suppressors of this phenotype identified SAM synthase, the enzyme which synthesizes the methyl donor SAM as a critical activator of cap methyltransferase activity [ 31].

Taken together, our results identify ATP as a critical activator of bestrophins, and reveal the molecular mechanism of an hBest1 patient-specific mutation.

ROS has been regarded as a critical activator of cell apoptosis, especially that induced by anticancer drugs [40].

KLF-1, a critical activator of BCL11A [55], and MYB, a potent activator of KLF-1 [57] 57] and negative regulator of γ-globin [58] had similar expression patterns and were significantly down-regulated at 12 h (p < 0.03).

The microarray analysis has revealed the downregulation of genes for several chlorophyll a/b binding proteins and suppression of the rice ortholog of GUN4, a critical activator of chlorophyll synthesis in Arabidopsis (Larkin et al. 2003).