Sentence examples for critical activation from inspiring English sources

Many proteins exist as precursor molecules, storing critical activation energies in precursor conformations, releasing potential energies when protein structure changes to expose sites needed to drive biochemical or immunological reactions (Dellisanti et al. 2011; Tompa 2012; Cook and Hogg 2013).

Higher concentration of this protein in the spring is consistent with critical activation of thyroid receptor during the breeding season.

Mammalian 9-1-1 has been implicated in the activation of the checkpoint kinase Chk1, a critical activation step for DDR [24].

Indeed, in this work we show that oligomerization of Hsf-1 is accompanied by a dramatic decrease in the interaction between Hsp90 and Hsf-1 (Figure 5G), highlighting the critical activation of Hsf-1 in response to MGO.

Thus, we believe that, upon TCR engagement and transcriptional activation, required "second signals" include those that prolong half-lives of many critical activation transcripts, and that this can be achieved through transmembrane signaling by a variety of molecules, including integrins.

Improved NO bioavailability may therefore protect barrier function by inhibiting the critical activation of TRPV4 channels in over-ventilated lungs.

Residues equivalent to N89, E262, V265, and S275, identified here as critical for activation of TAS2R16, have also been identified as important for activation in other TAS2Rs16, 41,42,43,44,45.

Mutational studies in live cells confirm that this mechanism is critical for activation of Btk in vivo.

4-1BB (CD137) is a TNF family member and is critical for activation and long-term maintenance of primed T cells.

These results demonstrate that the transmembrane region of the EPO-R is critical for activation by gp55.

Calcium signaling is critical for activation of T lymphocytes and has been proposed to be transduced through multiple calmodulin target proteins.