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We have fixed this criterion to a minimum of 6 repetitions for dinucleotide repeats (12 base pairs in length) and 5 for the others (15 base pairs in length for trinucleotide).
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This was a pragmatic trial, so we aimed to keep the exclusion criteria to a minimum.
Each criterion covers a separate aspect of good animal welfare and the list was chosen to encompass all potential areas of concern while at the same time keeping the total number of criteria to a minimum.
Inclusion criteria have intentionally been kept broad and exclusion criteria to a minimum in order to explore the efficacy of metyrapone treatment in as real world a setting as possible.
In this pragmatic trial we have kept the exclusion criteria to a minimum with the goal of maximising external validity and ensuring the results generalise to the target population.
Instead, we used our methodological validity criteria to provide a minimum standard to serve our primary purpose, which was to identify tests with strong and moderate diagnostic performance for use in clinical practice.
The standard similarity criterion was set to a minimum of 60% amino acid identity and 80% coverage of both proteins.
The concrete inclusion criterion was: Sentenced to a minimum prison sentence of ten months due to a violent or sex offense, or to court-ordered therapy by a court in the Canton of Zurich between August 2000 and December 2002.
In screening for eligibility, exclusion criteria were kept to a minimum.
Exclusion criteria are kept to a minimum.
Inclusion and exclusion criteria were kept to a minimum.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com