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All included studies were published between 2010 and 2014, suggesting that the inclusion criterion of studies published after 2000 was sufficiently conservative and that it is unlikely that any relevant articles were missed from earlier publication dates.
In the above-mentioned review [ 18], a systematic literature search on OCD and QoL identified only seven articles concerning children or adolescents, which were subsequently excluded from the review because of the selection criterion of "studies evaluating adults".
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We have used the criterion of studying the density of cholinergic interneurons in territories that receive only one type of cortical information, in order to minimize the effect of overlapping projections with different cholinergic neuronal densities.
Narrowing the inclusion criteria of studies increases homogeneity but also excludes the results of more trials and thus risks the exclusion of significant data [ 11].
The inclusion and exclusion criteria of study selection were developed (Table 2).
The studies were diverse in sample size and enrollment criteria of study population.
To propose and test a simple instrument based on seven criteria of study design to distinguish effectiveness (pragmatic) from efficacy (explanatory) trials.
We grouped study results according to two well-recognized criteria of study design quality.
In addition, selection criteria of study populations, sampling techniques and considered age groups differed.
Additional file 1: Inclusion and Exclusion Criteria of Study Participants in Clinical Protocol.
We examined 13 criteria of study quality (see Additional file 2).
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