In the near future, international criteria of exposure to inhaled CNTs will be established.
The strict selection criteria of exposure only to VCM reduced the sample size to 21 (figure 1).
For review of study quality including bias, individual studies were reviewed using GRADE guidelines for eligibility criteria, measurement of exposure and outcome, confounders and follow-up.
Where there were multiple studies per database we selected a 'best in class' study based on a number of factors including study quality, number of cases, eligibility criteria, measurement of exposure and outcome, confounders and follow-up.
We used the STROBE [ 17] criteria as a guide to consider key aspects of study design: sampling methods, definition of study population, inclusion and exclusion criteria, assessment of exposure, assessment of outcome(s), completeness of follow-up, treatment of missing data and treatment of possible confounding variables.
Titles and abstracts were independently reviewed by two people (MV, MKi) to retrieve potentially relevant studies on the basis of a broad range of criteria for exposure (work exposure) and outcome (health) to further determine eligibility.
34 We chose a fixed effect model because apart from the necessarily different approaches to identification of relevant cases described above the studies in CPRD and QResearch (which have similar sizes and similar methods of recording information) were comparable, using the same exclusion criteria, definitions of exposures and confounders, and the same models.
Because of the inclusion criteria of traumatic exposure and symptoms, all participants received the following components: (1) encouraging participation & psychoeducation; (2) cognitive coping/restructuring; (3) imaginal exposure; (4) safety; and, (5) finishing/wrap-up [ 16].
In the end, five proteins were found to satisfy criteria of surface exposure, conservation/expression in all strains as well as a significant titer in serum bactericidal assays.
A methodology is described for addressing the smoke toxicity component of fire hazard in a manner that permits the flexible application of exposure criteria according to desired fire safety objectives.
