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In the absence of any reliable surrogate markers of protection against tuberculosis (TB) the monitoring of vaccine-induced immunity using an effective assay for immune markers is considered the best selection criterion for moving a new vaccine candidate forward from Phase 1 and IIa safety and immunogenicity studies through into Phase IIb and Phase 3 efficacy testing.
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Dr. Tinetti served for four years on the Food and Drug Administration's advisory committee on non-prescription drugs, which ascertains whether a medication meets the criteria for moving from prescription-only status to over-the-counter.
"For months, we have laid out the criteria for moving forward.
In retrospect, more stringent criteria for moving to the second stage should have been used.
Such insight would allow the development of an interpretation strategy and specific criteria for moving from any point on the EPHC toward either the "exposure" or "effects" sides.
Despite the progress in defining criteria for trustworthy guideline development, gaps in research around guideline group composition and processes, determining and implementing criteria for moving from evidence to recommendations and developing recommendations about diagnostic tests and strategies are apparent.
The intervention had measurable criteria for moving from one stage to the next that enabled the therapist to judge if the parent and child had accomplished a level of skill at that particular stage.
The criteria for moving from FR1 to FR5 phase included: (1) earning a minimum of 20 reinforcers per session in two consecutive sessions; (2) varying in the number of infusions earned by no more than 20% in two consecutive sessions; (3) making at least 70% of all responses on the AL; (4) the passage of at least 2 weeks in the FR1 phase.
But, nonetheless, we are entitled to know the criteria used for moving an individual from the category of "criminal suspect" to "target".
What will be the new criteria the Obama administration sets for moving a prospective passenger to a higher level of scrutiny?
The reason for moving?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com