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Headache frequency was taken as a criterion for improvement or worsening of headaches.
The criterion for improvement was a reduction of 2 or more categories on the Disability Scale.
With this cut-off, in total 19 patients fulfilled the criterion for improvement or deterioration (n = 9 (6%), n = 10 (7%), respectively) in KOOS Pain.
In this study, panitumumab plus rilotumumab met the prespecified criterion for improvement in ORR, whereas any grades of rash, acneiform dermatitis, and paronychia were observed more frequently in patients who received a combination of rilotumumab and panitumumab compared with those who received panitumumab alone.
This was based on the patients' responses to a question about "being able to cope with the problem and do what you would like to do", with a response change from "not being able to cope" before treatment to "being able to cope" at followup considered as criterion for improvement[ 3].
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In conclusion, this study identified several important design criteria for improvement of the antiproliferative selectivity of the aroylhydrazone iron chelators.
Compared to placebo, a greater percentage of ocrelizumab-treated patients in the FEATURE study achieved the American College of Rheumatology 20% criteria for improvement (ACR20) at week 24.
"Time to improvement" was calculated from the date of KS diagnosis to the date of the first clinic visit that the patient met criteria for "improvement".
22 23 In addition, the American College of Rheumatology (ACR) criteria for improvement were assessed.
In addition, researchers should establish criteria for improvement and remission according to the BAI score, in primary care patients.
The primary efficacy variable in this study was the attainment of American College of Rheumatology (ACR) criteria for improvement of rheumatoid arthritis.
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