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For the evaluation of effect in animal studies during preclinical development of new anticancer agents, reduction in tumor volume is the most commonly used criterion for efficacy.
The main criterion for efficacy of our dietary intervention was the body weight loss by at least 5%.
The main criterion for efficacy was objective response rate; secondary criteria were time to progression, response duration, and overall survival (OS).
In line with previous methodology, 23 the clinical criterion for efficacy was the investigator's global improvement rating on a five-point scale (−1, worsened; 0, unchanged; 1, improved; 2, markedly improved; and 3, resolved).
Clearly, many of these storage-related red cell changes, which could affect blood flow and oxygen delivery in the recipients, reverse rapidly upon infusion, and probably account for the fact that survival of 75% of transfused cells at 24 hours can be used as an achievable criterion for efficacy following storage.
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Based on the standards of evidence for efficacious interventions laid out by the Society for Prevention Research [ 22], 46 strategies meet scientific criteria for efficacy by having consistent, positive outcomes from at least two high-quality experimental or quasi-experimental trials using a comparison group or interrupted time-series design (Additional file 1).
One of the criteria for efficacy will be the prevention of new hypomanic/manic episodes.
Rizatriptan provides relatively good freedom from pain and nausea though with poor pain relief, the reason for that might be the different criteria for efficacy in each study.
Thus, the trial met the prespecified criteria for efficacy of everolimus in this patient population.
Criteria for efficacy assessment were response rate, progression-free survival and overall survival.
The trial, therefore, met the prespecified criteria for efficacy of everolimus in patients with chemotherapy-refractory advanced endometrial cancer.
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