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Some PIP criteria were impossible to evaluate in cases with insufficient clinical information and history (e.g. information about an intact uterus).
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Evaluating the validity of this alternative hypothesis is difficult, as the presence and extent of a bias induced by these criteria is impossible to determine without a means of independent comparison.
Because diagnosis is made at the age of 3 years or older, verification of this hypothesis on the basis of current diagnostic criteria is impossible.
The fact that most of the children were being treated using medications typical for these conditions gives us some confidence that they were experiencing symptoms to a level of impairment warranting the use of psychiatric medications; however, which diagnosis they would actually meet criteria for is impossible to establish from this database.
When dealing with mitochondrial patients collecting a large group of patients that would meet these criteria is virtually impossible in a single centre.
Thus, consensus was impossible because the criteria were different.
Euthanasia was only considered in cases where recovery was impossible (criteria for recovery see [13]) and thus mortality can be considered representative of natural fire mortality.
While we conducted the review using established criteria [ 62] it is impossible to exclude certain sources of bias, particularly the possibility of having overlooked eligible studies.
Full text was obtained for those articles which met the inclusion criteria or where it was impossible to assess these from the title and abstract.
Evaluating sustainability outcomes of tourism partnerships with protected areas is challenging (Butler 1999; Murphy and Price 2005), mainly because every destination will have a different balancing point with respect to resource preservation versus development; thus, developing consistent criteria across destinations may be impossible (Tsaur and others 2005).
But it's impossible to know with certainty, because those diagnostic criteria were established after the start of the study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com