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Primary objectives are determination of the optimal doses for pazopanib (phase I) and the overall response rate according to RECIST criteria (phase II).
Four investigators (CC, LC, KL and KM) screened titles and abstracts for relevance in two phases based on the inclusion criteria: phase one eliminated all clearly irrelevant studies, phase two applied all inclusion/exclusion criteria listed above for the remaining studies.
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An additional 15 catch trials were interleaved randomly, presenting stimuli identical to those used in the criterion phase.
Each equivalent noise and motion coherence task consisted of three levels: a combined demonstration and criterion phase ('level 1'), a practice phase ('level 2'), and a threshold estimation phase ('level 3'level
As in the equivalent noise task, there were an additional 15 catch trials, which presented stimuli used in the criterion phase.
Dose escalation was according to the standard phase I criteria.
Phase B participants (n = 9) were recruited using the same criteria as Phase A. Additional inclusion criteria for the Phase B smoking cessation trial were being a current smoker who smoked at least 10 cigarettes/day, no reported period of smoking abstinence greater than three months in the prior year, no history of hypersensitivity to nicotine or adhesives, and motivation to quit smoking.
We identified seven RCTs meeting the inclusion criteria: three Phase III RCTs [ 13, 15, 18], Four Phase II RCTs (Table 1 and Additional file 1) [ 14, 16, 17, 19].
Design criteria of phase change microcapsules and preparation considerations were discussed in terms of desired applications.
Once the screening criteria from Phase 2 are applied to the list of ecosystem service modeling tools in Table 2, the following table of appropriate tools was identified (Table 3).
White blood cell and platelet counts and hemoglobin levels are used as inclusion and/or exclusion criteria in Phase I/II vaccine trials.
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CEO of Professional Science Editing for Scientists @ prosciediting.com