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For details about the recruitment criteria of study participants and the analysis of TMS-evoked EEG potentials see "Protocols and procedures" and "Data Analysis" sections, respectively.
The studies were diverse in sample size and enrollment criteria of study population.
To propose and test a simple instrument based on seven criteria of study design to distinguish effectiveness (pragmatic) from efficacy (explanatory) trials.
The inclusion and exclusion criteria of study selection were developed (Table 2).
Twelve healthy subjects (5 M) age 20.5 years (range 19 29) with an average of 14.8 years of education (range 14 20) who satisfied inclusion/exclusion criteria of Study 1 (described above), but did not participate in Study 1, participated in Study 2. A novel anticipation paradigm (Fig. 2) was administered during functional magnetic resonance imaging (fMRI).
In addition, selection criteria of study populations, sampling techniques and considered age groups differed.
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Narrowing the inclusion criteria of studies increases homogeneity but also excludes the results of more trials and thus risks the exclusion of significant data [ 11].
Four randomized controlled trials (RCT) and one case control study met the inclusion criteria of our study.
We included all studies meeting these criteria irrespective of study design, methodological quality or outcomes measured.
Seven trials met the inclusion criteria (details of study flow are given in Figure 1).
Enrolment details (dates of enrolment, period of enrolment, age of child at recruitment, enrolment criteria, status of study).
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