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Studies of population prevalence of MCI in similar age groups, using age adjusted psychometric criteria of memory impairment, yield lower estimates, typically 2 5% [ 6, 7].
All AD patients met the standard diagnostic criteria of memory impairment and had progressive impairment of memory and impairment in at least one other cognitive domain [ 15].
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Furthermore, the study by Solfrizzi et al in some cases applied the criteria of subjective memory complaints retroactively, since the study did not require subjective memory impairment.
In contrast, objective operational measures for the remaining 3 criteria of objective memory impairment, intact general cognitive function, and no functional impairments were uniformly provided.
Based on our results, we partition the studied assemblers into different classes based on the criteria of time, memory, and quality.
Inclusion criteria were complaints of memory problems of at least 6 months duration, an estimated IQ score >80, and a score of 24 or higher on the Mini Mental State Examination (MMSE) [ 31].
No studies operationalized the first criterion of subjective memory complaint [ 39], although complaints were assessed during interview [ 28].
Our results confirmed that subjective memory complaint is not associated with APOE status [ 53], and Fisk et al. [ 6] found that eliminating the criterion of subjective memory complaint from the definition of MCI had no impact on the relative risk of subsequent cognitive decline.
For the age-matched control population the inclusion criteria were: (i) absence of memory complaints or any other cognitive symptoms, (ii) preservation of general cognitive functioning, and (iii) no active neurological or psychiatric disease.
Dementia was diagnosed according to DSM-IV criteria, requiring an impairment of memory with one other abnormality of cognition, functional disability, and preservation of consciousness.
Their MCI definition resembles the Petersen criteria, which require the presence of memory complaints with pre-served basic ADL and no or minimal impairment of complex ADL [ 6].
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