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Three compounds satisfied criteria of interaction analysis, competitively inhibited recombinant Stat3 binding to its immobilized pY-peptide ligand and inhibited IL-6-mediated tyrosine phosphorylation of Stat3.
Three compounds satisfied criteria of interaction analysis, inhibited recombinant Stat3 binding to its immobilized pY-peptide ligand and inhibited IL-6-mediated tyrosine phosphorylation of Stat3.
A compound was selected for purchase and biochemical testing based on fulfilling the criteria of interaction analysis (CIA): 1) global minimum energy score ≤−30; 2) formation of a salt-bridge and/or H-bond network within the pY-residue binding site; and 3) formation of an H-bond with or blocking access to the amide hydrogen of E638.
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Biological interaction between two genes was estimated using departure from additivity of effects as the criterion of interaction, as proposed by Rothman [ 19].
Biological interaction between two genes was estimated using departure from additivity of effects as the criterion of interaction, as suggested by Rothman [ 25].
Interaction between the genotype and mineral oil was evaluated using departure from the additivity of effects as a criterion of interaction, as suggested by Rothman and colleagues [ 22].
The potential interaction between adolescent obesity and prior IM was analysed using departure from additivity of effects as the criterion of interaction and was evaluated by calculating the attributable proportion due to interaction (AP) together with a 95% CI.
We chose a 23 inch full HD monitor as the display device based on the criteria of minimal interaction with the patient, minimal discomfort to the surgeon, and low cost.
This includes parsing interactions between genes, chemicals, and diseases, finding which chemicals have co-interactions with genes, finding unique interactions and directional interactions between chemicals and genes, finding interaction characteristics for disease-gene and disease-chemical interactions, and selecting inclusion criteria for interactions of interest to develop each network.
In this process, all of the parameters, except for the number and the clustering criterion of the interaction hotspots, are considered as independent.
The elastic characteristics of the PCJ are derived from a generic biological muscle mechanical behavior model and then customized according to the force-safety criteria of physical Human/Robot Interaction (pHRI) into a Hunt Crossley contact model.
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