Then, we performed gene functional annotation for these genes by using DAVID bioinformatics enrichment tools [ 27, 28] to identify kidney-related disease genes, following the classification criteria of Online Mendelian Inheritance in Man (OMIM database).
Tools like AgileExomeFilter (Watson et al., 2014) allow filtering of variants on a variety of criteria, such as inheritance mode, regions of autozygosity, sequencing quality or variant types thought to mostly be benign, for example synonymous substitutions or small in-frame insertions or deletions.
The approach we have presented for computing similarity scores relies on pre-selecting groups of cases based on the presence of rare variants fulfilling certain criteria, such as presumed mode of inheritance.
Although none of the other families (22 with a dominant pattern of inheritance) fulfilled the criteria for screening, the APC gene had been screened in 20 of the families and the MUTYH gene in 15 of the families without any clearly pathogenic mutations found [ 20, 21].
We then compared models by calculating the Akaike information criterion and Akaike weights for each mode of inheritance.
Obviously, the presence of this kind of elements in CNVs of unknown consequences should be used with caution together with other pathogenicity criteria, such as the gene content or the mode of inheritance.
We examined SNP × PM2.5 interactions under additive, dominant, and recessive models of inheritance, and in our ΔDBP models 32 associations in 21 SNPs met criteria for ΔDBP in the discovery data set and were replicated.
Shīʿite law rejects the criterion of the agnatic tie and regards both maternal and paternal connections as equally strong grounds of inheritance.
In terms of inheritance, drought tolerance is a quantitative complex trait with low heritability for which appropriate selection criteria are largely absent (Schneider et al. 1997, Blair et al. 2010).
OBJECTIVE: To develop diagnostic criteria for a familial form of antiphospholipid antibody syndrome (APS), identify families with >1 affected member, examine possible modes of inheritance, and determine linkage to potential candidate genes.
