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In this paper, we describe where each of the Air It Out study components falls along the pragmatic explanatory continuum regarding participant eligibility criteria, intervention and comparison condition design, follow-up and outcomes, compliance and adherence assessments, and analysis.
The included studies were analyzed and cross-checked independently by two authors to extract the following information: study design, objectives and discussion, participants and eligibility criteria, intervention used, variables and measurement, key outcomes, and conclusions.
Studies were selected based on predefined criteria: intervention with tea as the sole experimental variable, placebo-controlled design, and no missing data on FMD outcome or its variability.
Information defined a priori included sample sizes, baseline characteristics, inclusion criteria, intervention details, study duration and number of contacts.
Narrow controls designed to optimize the internal validity of a trial (that is, inclusion/exclusion criteria, intervention protocol) can compete with and compromise overall generalizability [ 41].
Study details (inclusion/exclusion criteria, intervention and comparison treatments and outcome measure details) were extracted and summarized (see Additional file 1: Appendix 2).
Similar(44)
The majority of studies had well-defined in- and exclusion criteria, interventions and outcome measures.
There were no changes to eligibility criteria, interventions, examinations, data collection, methods of analysis, and outcomes.
Based on the findings from GRADE criteria, interventions were summarized as effective, promising or ineffective.
Data routinely abstracted from studies are: study design, population characteristics, eligibility criteria, interventions, numbers randomized/treated and analyzed, and results.
Data were extracted on trial design, study setting, participants, inclusion and exclusion criteria, interventions and outcomes evaluated and results.
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