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High grade events (Common Toxicity Criteria grades 3 to 5) were reported inconsistently in the articles, and the information regarding attribution to investigational drugs was incomplete.
Radiographs were evaluated according to the Ahlbäck criteria, grades I to V, with grade V representing the most severe findings [ 29].
The overall response was determined as "favorable" in patients with esophageal candidiasis if clinical symptoms and signs of Candida infections (odynophagia, dysphagia, and heartburn) resolved and follow-up endoscopy results indicated at least a two-grade improvement (or return to Grade 0) in the predefined criteria (Grades 0, 1/2, 1, 2, 3, and 4) [ 11].
Using common toxicity criteria grades (CTC, version 2.0) to classify neutropenia, 49 patients (28.0%), 33 patients (20.3%) and one patient (<1.0%) in the 8 mg/kg, 4 mg/kg and control groups, respectively, had transient neutropenia at some time during the study.
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Mean maximum severity scores for EAE were done using the following grading criteria: Grade 1. limp tail; grade 2. limp tail and weak hind limbs; Grade 3. hind limb paralysis; Grade 4. fore limb paralysis; Grade 5. moribund; Grade 6. death.
Two studies [ 19, 23] included patients with histologically unfavorable criteria (grade V).
The most common clinical side effect was headache common toxicity criteria grade I.
Patients were excluded if they had National Cancer Institute common toxicity criteria grade ≥2 peripheral neuropathy.
Common toxicity criteria grade (CTCg) II vomiting was recorded at all dose levels.
Good neurological outcome was classified as Pittsburgh Cerebral Performance Criteria grade 1 to 2 at hospital discharge [ 2].
This study highlights the flaws within the CTC (common toxicity criteria) grading scale, especially in identifying rectal injury.
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