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But before we assume that diplomacy can't work, it is worth considering that Iranians are now facing crippling pressure and that their leaders have in the past altered their behavior in response to such pressure.
Some of Britain's leading charities will urge the Government to let them make a "radical intervention" at accident and emergency (A&E) departments in a bid to relieve crippling pressure on medical staff.
Much more than oil, natural gas prices have been under crippling pressure this year after rising to more than $13 per thousand cubic feet last summer.
Sometimes the crippling pressure of being a person mounts and you feel trapped and alone and, quite simply, sad.
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Interestingly, if we didn't have the secret weapon of crippling peer pressure, this method of performance enhancement may never have been tested.
Years of talks with Iran have gone stale, and are accompanied by increasing threats and crippling economic pressures.
Ultimately, Ayatollah Khamenei will have to decide what poses a greater threat to his rule: ending his quest for nuclear weapons or stubbornly pursuing them as crippling economic pressures mount.
He predicted that solar panel manufacturers in Europe and the United States would also face crippling financial pressures and that the long-term survivors in the industry would be manufacturers in Taiwan, who have low costs and are not subject to the American import tariffs or the likely European tariffs.
Both cited their belief that increasing the pressure of crippling sanctions may yet alter Iranian behavior.
The aim was to relieve both the international pressure (a crippling economic boycott) and the increasing inter-factional violence that have plagued the Palestinian Authority (PA) since Hamas took over power from Fatah in March.
The clot can grow, further increasing the pressure and progressively crippling brain function, in a cascading process beyond the reach of homeostasis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com