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Although a number of studies have measured CRF in breast cancer patients, there is currently limited data regarding expected CRF values in this patient population.
Together, these findings suggest that CRF-1 receptors mediate pain and implicate CRF in this regard.
Converging findings support a role for extra-hypothalamic CRF in the mediation of the stress response.
Extensive literature suggests a role of CRF in alcohol use disorder (AUD).
This is the first evidence for a role of CRF in adolescent erectile response.
Two studies have found higher levels of CRF in cerebrospinal fluid (CSF) in PTSD (Baker et al, 1999; Bremner et al, 1997).
Consistent with these findings, in vivo microdialysis revealed higher extracellular levels of CRF in the BNST and CeA during alcohol withdrawal13,14.
Zeng and colleagues28 assessed the effectiveness of acupuncture for CRF in various types of cancer patients (Table 5 and Appendix 4).
Increased hypothalamic CRF in PTSD is thought to explain, in part, the blunted ACTH response to CRF in PTSD found in some (Heim et al, 2001; Smith et al, 1989) but not all studies (Kellner et al, 2002; Rasmusson et al, 2001).
In this study, CRF in Wistar rats was induced by fed with 0.75% adenine and diosgenin was treated everyday at the dose of 40 mg/kg.
This is consistent with a previous study that showed that the potentiation of excitatory transmission by CRF in the BNST is only observed in a small population of BNST neurons27.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com