Sentence examples for creation of new binding from inspiring English sources
Creation of new binding sites in regulatory regions is an intuitive case of adaptive regulatory evolution.
Therefore, binding chain reactions can occur, in which interaction between proteins A and B induces structural changes in B or/and A, leading to the creation of new binding site(s) necessary for the additional interactions between A and B and to the strengthening of the AB complex.
Atomistic molecular dynamics and potential of mean force calculations show the preservation and potential creation of new atRA binding sites with a binding energy of −41 kJ/mol.
Explicitly, an SNP can lead to (1) a loss of the binding site, (2) a change of binding site, meaning that due to the SNP a different TF binds the region or that the same TFs can bind to the site but with a different affinity, (3) a creation of a new binding site in a region where previously no binding site was known, or (4) no change at all.
Such amplicons were absent in the normal males and, as expected, in the females, suggesting creation of new primer binding sites in the exposed males.
TEs contribute to a multitude of genomic regulatory functions and have been identified as a rich source for the creation of new species-specific TF-binding sites in mammals (Wang et al. 2007; Bourque et al. 2008; Kunarso et al. 2010).
As detailed in the Results section, we suggest that the SCL E47 heterodimerization interface is more stable than either individual homodimerization interfaces and that binding of LMO2 induces subtle conformational changes resulting in the creation of new hydrogen bonds.
The unique binding pocket on HER-2 for pertuzumab provides an important target domain for creation of new anticancer drugs.
If the observed ΔS in real binding sites is greater on average than the ΔS expected for binding sites arising from background sequence in the absence of selection, this indicates adaptive creation of new sites.
