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WikiPathways works under the same principles: users can contribute to the open-source pathway resource by suggesting new pathways to be added or by creating novel pathways.
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It allows the user not only to browse the defined pathway, but also to create novel pathways.
But here's a quick guide to how to use it anyway, just to win an argument: Use the word 'neuroplasticity', ideally in a sentence For example: "I've changed my mind about the SNP because the neuroplasticity of my brain has created novel neural pathways".
Fusions may drive oncogenic growth by joining a proliferation-inducing gene to an active promoter, by disrupting the function of tumor suppressor genes, or by creating novel functional products that rewire the biochemical pathways that regulate cellular division [ 1].
Finally, the prospects for future advances needed to achieve much more efficient bio-based production of advanced biofuels are discussed, focusing on designing advanced biofuel production pathways coupled with screening, modifying, and creating novel enzymes.
The idea of introducing an entirely foreign metabolic pathway opens up opportunities for understanding metabolism and creating novel potential therapeutic approaches.
Synthetic biology provides a significant platform in creating novel pathways/organisms for producing useful compounds, while it remains a challenge to enhance the production efficiency.
Regulatory reform is needed to re-establish feasible and meaningful traditional antibiotic pathways, to create novel limited-use pathways that focus on highly resistant infections, and to harmonize regulatory standards across nations.
Pathway reversibility creates novel circumstances where synthetic lethality can potentially be exploited in targeting recombination pathways during anti-cancer therapy.
Combinatorial biosynthesis utilizes the enzymes from antibiotic (and other natural product) biosynthetic pathways to create novel chemical structures.
How does the ability to digitally hypothesize, design, and engineer the metabolic pathways of an organism, or create novel organisms, change the dynamics of life science research and industry?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com