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Numerous mechanisms of action were optional for such action among them was the strong suppression of E2F1 that inhibits growth by thwarting cell cycle progression and fasters differentiation by creating a permissive environment for cell distinction [11].
Administration of MSCs to rodents reduces the glial scar and also reduces the expression of inhibitory glycoproteins, thereby creating a permissive environment for neurite outgrowth [24], [80].
Increasing evidence suggests that EGFL7 regulates blood vessel development by creating a permissive environment for angiogenesis [ 5].
Variation in either gene could predispose to RA, therefore, by creating a permissive environment for an up-regulated immune response.
The loss of genomic stability appears to be a key molecular and pathogenetic step occurring early in tumourigenesis creating a permissive environment for the occurrence of alterations in tumour suppressor genes and oncogenes [ 3].
In addition, both direct and indirect interactions between cancer cells and the mesenchyme are responsible for triggering the activation of the tumor-associated stroma (e.g., desmoplasia), creating a permissive environment in support of tumor development and cell invasion [ 5, 13, 16].
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(… somewhat hard to figure out what is being discussed here. I'll give you a few of the words..) "crowdsourcing... poilicies that create a permissive environment..".
The switch of Schwann cells to a proliferative state, secretion of trophic factors, and the presence of extracellular matrix (ECM) molecules (such as collagen, laminin, or fibronectin) in the distal stump are key elements to create a permissive environment for axons to grow.
Thus, the presence of t-Darpp appeared to create a permissive environment for enhanced Darpp-32 expression that otherwise could not be achieved.
Therapeutic transplantation of stem cell populations may promote functional recovery by providing trophic support, modifying the host environment to create a permissive environment for endogenous regeneration/repair, or by replacing neurons and/or oligodendrocytes [1], [2].
Collectively, these downstream effects create a permissive environment for tumor initiation, growth and progression [ 20- 22].
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