Sentence examples for creating a new specificity from inspiring English sources
Testing six more recent ancestors showed that, over a billion years of evolution, this amino acid preference became broader to include both proline and arginine and that some modern protein kinases subsequently evolved and specialized to prefer arginine at the +1 position, thus creating a new specificity.
The SNP g.390A > G also created a new specificity protein 1 transcription factor binding site in the lysozyme gene.
An estimate of the rate of appearance of new specificities can be, however, obtained under the assumption that a single amino acid change at a positively selected amino acid site is enough to create a new specificity.
Based on these inferences, and the assumption that a single difference at a positively selected amino acid is enough to create a new specificity, one new specificity is estimated to appear every 7.7% per site synonymous divergence or alternatively every 1.92% per site nonsynonymous divergence.
We created a new DNA recognition specificity for tetracycline repressor (TetR) binding to the tet operator variant tetO-4C5G containing four bp exchanges compared to tetO.
It should be pointed out that, in the generator model, new specificities are created through several steps where intermediate steps have some chance of not being recognized as a new specificity [ 40].
This could reflect the lower binding specificity of C/EBPα, since it is easier to create a new site if the factor can bind to many different sequences.
