Although JNCL is a recessive trait generally thought to be due to a loss-of-gene function, it is possible to identify functional properties of the CLN3 protein by creating a gain-of-function condition.
They will move the ball quite a bit but with the team, and the squad, he has picked we are going to see some big ball carrying – take a look at that centre pairing of Jonathan Davies and Roberts – to create a gain line advantage.
The mutant genes or changes in gene expression create a gain of function, typically resulting in either constitutive activation of a protein (the drug target) or acquisition of neomorphic traits that drive tumorigenesis.
Similarly to the scapular plane of the body where the overhang creates a gain in adduction, a gain in internal and external rotation can be expected in the transverse plane of the body (Gutiérrez et al. 2008 a, Karelse et al. 2008).
By swapping loop motifs, we created a gain-of-function mutant of BubR1 that can bind kinetochores in the absence of Bub1, and a loss-of-function mutant of Bub1 severely impaired in autonomous kinetochore binding.
In the era when the nation was facing the dreaded polio epidemic, polio vaccine was developed and tested with government assistance, and distributed at low cost, creating an incredible gain for the entire world.
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Global markets have rallied substantially over the past few years, creating a potential capital gains tax burden.
Anderson's son, Eddie Anderson Jr., took responsibility for creating a foundation and gaining the needed approvals for the rehabilitation center his father envisioned.
