Indeed, the observation that BET-BRD inhibitors (e.g., JQ1) effectively block cellular growth through transcriptional repression of c-Myc in mouse models has created the rationale for clinical trials in c-Myc-dependent cancer types (Mertz et al., 2011).
Initially, Gelbart and Reynolds handwrote letters in response to the feedback, but eventually, due to the overwhelming number of letters, a form response was created explaining the rationale of their decisions.
We particularly investigate the customers' rationale for creating the buyer group, as well as the rationale that leads the seller to react using a KAM program as a selling strategy to segment a market configured by customers in a buyer group and by the remaining independent customers.
The synthesis of function (national school system with local curriculum adaptation) and beliefs (education and work-life related individual attitude variables) designs added to the rationale for creating the measurement instrument used in this research.
The scientific landscape (e.g. advances in genomics), healthcare reform, and policy and socioeconomic issues all influenced the rationale for creating the NCCCP as a public-private partnership [ 1].
Elaborating on his rationale for creating the gallery, Mr. Büsser returned to a favorite topic: the mediocrity of 20th century watchmaking.
Approach 1 was created based on the rationale that coding for BM on a health care claim would occur only when the patient had a diagnosis of BM.
We decided to use the randomForest classifier trained with the three non-redundant features shown in Figure 1B to create OncodriveROLE, under the rationale that features representing the three independent groups could provide more information to classify novel drivers.
Psychologists call this the "bystander effect," and it happens when your brain creates a rationale around why you shouldn't take a stand.
"China's leaders are consistently asked what their position is and whether or not they can help, and it puts them in an awkward position … It could be that over time it creates a rationale for a new foreign policy – that they decide they have to be more active and more willing to take the initiative," said Taylor Fravel of the security studies programme at the Massachusetts Institute of Technology.
