The sentence 'creates a major challenge' is correct and usable in written English.
You can use it when writing about a difficult task or problem that must be solved. For example, "The decreasing resources available for education creates a major challenge for school administrators."
The increased emergence of drug resistant microbes creates a major challenge to the scientific community for successful development of effective therapeutics.
But the departure of Mr. Hester, 52, creates a major challenge for the bank: finding a banking executive with the skills and stomach to navigate the continuing restructuring and the increasing political heat.
Oral processing of solid foods is a highly dynamic and complex process; this creates a major challenge to elucidate the role of various components, hierarchical structures and phases on foods' organoleptic properties.
The significant amount of missing data creates a major challenge (for this task).
The interconnectivity and complexity of cellular and molecular interactions between the immune system and bone tissue creates a major challenge to develop therapeutic approaches that can specifically target one system without detrimentally affecting the other.
However, the occurrence of resistance limits treatment options and creates a major challenge for clinicians.
This creates a major challenges to accurately monitor child mortality, especially among children 5 years and older, and it underscores the need for adequate systems to track and record births and children's deaths.
The high and sometimes inappropriate use of antibiotics has accelerated the development of antibiotic resistance, creating a major challenge for the sustainable treatment of infections world-wide.
