Sentence examples for create substitutions from inspiring English sources

A powerful method for probing possible inner-sphere coordination sites is to create substitutions of functional groups that introduce biochemical and spectroscopic specificity.

To further investigate the allosteric mechanism of Sac1, we utilized structure information about Sac1 and created substitutions to perturb the catalytic behavior of Sac1.

We study the characteristics of the newly created substitution boxes and highlight the improved performance parameters and their usefulness in practical applications.

Our approach was to create cumulative substitutions, first at those loop regions where the most striking amino acid differences between Pla and Epo are, and then at the amino acids located on the extracellular side of the protein above the lipid bilayer.

Saposin C-deficient mice were created by knocking in a codon change to create the substitution cysteine-to-proline (C→P) substitution in saposin C.

Mutagenic DNA primers (table 1) were designed to create alanine substitution at residues K189 and D159 in GxxxxGKT and DExx motifs of rNSs respectively.

The foundation models described above are combined by a fixed-effect mixture model to create RNA substitution models, where partitions are specified a priori.

It has been suggested that recombination hotspots can create strong substitution hotspots that are correlated with gene density that drive the evolution of GC content (Duret and Arndt 2008; Tatarinova et al. 2010).

BGC can create strong substitution hotspots, thereby leading to spurious signatures of positive selection (Dreszer et al. 2007; Galtier and Duret 2007; Duret and Galtier 2009; Sumiyama and Saitou 2011).

In the context of protein-coding sequences, mutation primarily creates new substitutions, which leads to a broad variation in GC content.

The sequence scrambling creates nonconservative substitutions at invariant key functional domain positions, resulting in the highest possible sequence variant severity score.