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Understanding and implementing the principles that create robustness in complex adaptive systems can mean the difference between survival and extinction.
"We spent a lot of time sitting with developers, looking at what they can enable, what their data structure was, how to pull their experience back into UP, how you really create robustness around them, how to build APIs that work dependably and how we can make sure users can get this stuff".
Proteins that interact with the largest number of other proteins in the protein-protein interaction network could potentially buffer mutations at each interacting locus, and are therefore predicted to be under stronger selection to create robustness (Figure 1).
The production pathway should preferably be transferred into one of the common industrial microorganisms such as E. coli or S. cerevisiae, to create robustness of the producing organisms throughout the process.
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For example, multiple RNA-binding proteins with similar splicing regulatory activities might bind the same motif and this functional redundancy creates robustness in a splicing decision.
This creates robustness to noise by making the active monomer concentration less dependent on the total level of expression of that protein [ 29, 30].
They argued that Hsp90 is an evolutionary 'capacitor' that creates robustness to the effects of mutations, allowing genetic variation to accumulate in a cryptic form, to be released later.
Herein, we created a new robustness analysis method called 'consistent robustness analysis' which intends to evaluate model robustness independently of operating parameters.
Because different people produce different accelerations when they move, Sapsis says that his design goal is fairly simple: to create consistency and maintain robustness.
On the other hand, computational methods are being used in the recent decades in order to create inexpensive, rapid and robustness models to estimate gas oil MMP.
Despite the absence of any clearly related gene or activity, we describe possible scenarios by which tetherin arose that exemplify how protein modularity, evolvability, and robustness can create and preserve new functions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com