The activation of RAF has been shown to occur either through an activating point mutation (BRAF V600E), or much more frequently, through genomic alteration on 7q34 which creates a tandem duplication between the KIAA1549 gene and the BRAF gene kinase domain [10,11].
The arrangement of homologous sequences and I-SceI sites in the donor DNA defines two targeting strategies, Ends-In and Ends-Out, creating a tandem duplication or deletion of the target gene, respectively.
We suspect that a gene-duplication has created a tandem array of ycf3-like regions (ψ ycf3; colored in light blue and dark blue in fig. 1 A); one seemingly encodes a functional protein, and the other is most likely nonfunctional due to a large deletion (supplementary fig. S4, Supplementary Material online).
The deal creates a powerful tandem — the world's biggest online search and advertising engine, paired with powerhouses from the music industry —aiming to take on China's leading search engine, Baidu, whose Web traffic has grown partly because of its links to free, unlicensed music.
Due to the sequencing of the human genome by the Human Genome Project (9, 10), it is now possible to analyze the sequence of the human genome and create a listing of all tandem repeats in the genome.
For Ms. Sigman, who formed her company, Thinkdance, in 1998 — the same year she earned a Ph.D. in philosophy from Princeton — intellect and imagination work in tandem to create a theatrical experience.
Facebook and Twitter have become ubiquitous, he said, as has the presence of always-on, location-aware smartphones that work in tandem to "create a sixth sense that surfaces data and information that already exists around you".
The Appmates and the iPad work in tandem to create a pretty novel play experience.
It's like a body of systems all speaking to each other, working in tandem to create a comprehensive experience that optimizes your efficiency within any given environment.
