Sentence examples for create a new specificity from inspiring English sources
An estimate of the rate of appearance of new specificities can be, however, obtained under the assumption that a single amino acid change at a positively selected amino acid site is enough to create a new specificity.
Based on these inferences, and the assumption that a single difference at a positively selected amino acid is enough to create a new specificity, one new specificity is estimated to appear every 7.7% per site synonymous divergence or alternatively every 1.92% per site nonsynonymous divergence.
The SNP g.390A > G also created a new specificity protein 1 transcription factor binding site in the lysozyme gene.
Testing six more recent ancestors showed that, over a billion years of evolution, this amino acid preference became broader to include both proline and arginine and that some modern protein kinases subsequently evolved and specialized to prefer arginine at the +1 position, thus creating a new specificity.
This could reflect the lower binding specificity of C/EBPα, since it is easier to create a new site if the factor can bind to many different sequences.
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