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Mutations in both genes have been rarely described in MSI sporadic CRC (1).
Eight patients (CRC: 1; non-CRC: 7) were likely to be affected by both, anxiety disorder and depression.
Fifteen patients (11.5%) with possible anxiety disorders were identified by HADS-A (CRC: 1; non-CRC: 14; p=0.002).
Up to 10percentt of adults have a first degree relative with CRC, 1 which increases their risk of developing CRC.
Using genome-wide association studies (GWASs), we have identified 14 regions that contain tagging single nucleotide polymorphisms (tagSNPs) associated with the risk of colorectal cancer (CRC) (1).
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1 Multiple professional organisations have recommended screening for CRC 1 5 and many previous studies have demonstrated the cost-effectiveness of CRC screening.
All patients had metastatic CRC (≥1 metastatic site) and had received 1 5 lines of chemotherapy during the metastatic stage.
Global DNA hypomethylation is frequently observed in various malignancies including colorectal cancer (CRC) [ 1, 2], where it is thought to play a pivotal role in carcinogenesis [ 3].
Prevalence of liver diseases is increasing worldwide, and fatty liver and liver cirrhosis are known risk factors for colorectal cancer (CRC) [ 1, 2].
Until recently, 5-fluorouracil (5-FU) in combination with folinic acid (FA) has been the mainstay of treatment for advanced colorectal cancer (CRC) [ 1, 2].
Screening for colorectal cancer is a beneficial, cost-effective way to advance the public's health by reducing the incidence and mortality of CRC [ 1, 5].
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