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And for every seemingly crazy target that was subsequently met, the next one became more credible.
Bamford made tons of money playing the "Crazy Target Lady" in advertisements earlier this decade, banking on her own experience with mental health.
Others, such as James Hansen, a former NASA climate chief turned activist, said 2 degrees is too much warming, calling it "a crazy target to have; you cannot say that's a safe guardrail".
On the flip side of the Target coin, we have the 'Crazy Target Lady' and no, that's not a reference to Kristen Wiig's Target saleswoman skit on Saturday Night Live.
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A playwright and actress who lives with BD developed a stage performance - 'That's Just Crazy Talk' - targeting stigmatizing attitudes towards BD.
Are target boards crazy to agree to this?
Now, she's one of the most in demand stars in Hollywood -- "The Help," as she mentioned, is a highly anticipated new book-to-film adaptation of Kathryn Sockett's civil rights novel -- and she'll also star as Ryan Gosling's lady target in "Crazy, Stupid, Love" in perhaps the summer's most exciting romantic comedy.
I met black kids in there for small amounts of drugs, who said once they are known to police for selling drugs they get targeted like crazy.
"We can actually go for this crazy idea that you can target genes that control the aging process".
The schools face a number of challenges along the way, least of all convincing sceptics that such a huge fundraising target isn't crazy.
"But I know this group of players are still good because I'm not crazy when I said my target was reaching the final of the World Cup.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com