Exact(10)
For the fifteen million conformers used in this study, it took about four CPU years to compute the shape fingerprints using 64-bit 3-GHz Intel dual-core Xeon processors.
Computers simulated 2 players playing each other as well as possible for 900 CPU years, iteratively improving complex strategies (terabyte databases of all possible moves and responses) until they were provably so good that no one could have an advantage of more than 1 big blind per 1,000 hands.
Using RP55, the time to perform an equivalent BLAST search is only 0.23 CPU years, a nearly 20-fold reduction.
For example, the computation time to perform an all-against-all BLAST search of the entire UniProtKB is approximately 4.1 CPU years.
Firstly, running Infernal for all Rfam models takes around 25 CPU years.
While individual queries may only take seconds per CPU, aligning 100 million of them would require more than 3 CPU years.
Similar(50)
Secondly, the pairwise alignments take in the order of 1 CPU year per genome we aligned against the pig genome.
In total we spent more than 10 single-CPU-years of computing time on the optimizations presented here.
By using large-scale computational platforms, huge docking simulations can require a total computational time on a single core of many CPU-years [ 39].
Computing orthologs between all complete proteomes has recently gone from typically a matter of CPU-weeks to hundreds of CPU-years, and new, faster algorithms and methods are called for.
About 156 CPU (core) years of computation time was required to compile the necessary simulation data.
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