Moreover, HPT and CPT thresholds were lower at all sites except over the TA muscle (P < 0.01).
In the ON state, the PPT and CPT thresholds in PD patients were lower than in controls at all points, except over the TA (CPT) and the second metacarpals (PPT) P < 0.01.
Capsaicin, a topical drug for pain relief that affects small nerve fibers, was found to elevate CPT thresholds for small myelinated and unmyelinated nerve fibers but not for large myelinated nerve fibers (Kiso et al. 2001).
± 27.8 168.1 ± 32.5 322.3 ± 93.2 CDT cold detection threshold, WDT warm detection threshold, CPT cold pain threshold, HPT heat pain threshold, MDT mechanical detection threshold, MPT mechanical pain threshold.
Thermal testing consisted of testing for Cold Detection Threshold (CDT), Warm Detection Threshold (WDT), Cold Pain Threshold (CPT) and Heat Pain Threshold (HPT) and Thermal Sensory Limen (TSL) by using the methods of limits.
A battery of 4 thermal QST parameters was used: cold detection threshold (CDT), warm detection threshold (WDT), cold pain threshold (CPT), and heat pain threshold (HPT).
To establish differences in sensitivity and specificity of the CHC method with different contiguous point thresholds (CPT), correlations between CPT and the percentage of regions encompassing 'conventional LOH' or the distance of regions from 'conventional LOH' were derived using Pearsons correlation and the full data set for each CPT.
Eight parameters were measured, in the following order: vibration detection threshold (VDT), pressure pain threshold (PPT), mechanical pain threshold (MPT), mechanical detection threshold (MDT), warm detection threshold (WDT), cold detection threshold (CDT), heat pain threshold (HPT), and cold pain threshold (CPT) [ 21].
Likewise for somatosensory gain, thermal hyperalgesia (G1) was recorded if gain-of-function in cold or heat pain thresholds (CPT or HPT) were found (absolute or relative abnormality).
To identify cold pain thresholds (CPT) and heat pain thresholds (HPT), participants were asked to push a switch when the cold or warm sensation first became painful [ 39].
Verbal pain rating [using the 11-point numerical rating scale (NRS)] was used to assess the intensity of cold and heat pain thresholds (CPT and HPT).
