Exact(15)
Fig. 8 Post-therapy assessment of Clinical Pulmonary Infection Score (CPIS) in study groups.
It would be worth validating this 'new' CPIS in another prospective study.
To evaluate the CPIS in diagnosis of and monitoring the course of illness in children with VAP.
The APACHE II score and the modified CPIS in patients with negative cultures are outlined in Table 4.
CPIS in the first 48 hours showed a negative predictive value for pneumonia of 89%, and SQTA with no microorganism growth a negative predictive value of 96%.
The mean changes in CPIS in the de-escalation group were higher, although this result was statistically insignificant, than in the non-de-escalation group.
Similar(45)
No difference in CPIS was shown in both groups (3.8 vs 4.5, p = 0.12).
Even if these values are fairly acceptable, we should also consider that the CPIS score in selected population (i.e. brain injury) [11] scores even better: 97% sensitivity and 100% specificity and question the role of PCT as unique screening test for VAP early diagnosis [12].
CPIS levels in the patients with VAP were significantly higher than the patients with VAP in the days after the diagnosis.
The Clinical Pulmonary Infection Score (CPIS), utilized in the study by Abdel Gawad and colleagues, is based on five clinical parameters - fever, leucocytosis, purulence of secretions, oxygenation, extent of radiographic infiltrates - and strengthened by cultures from the lower respiratory tract (most often broncho-alveolar lavage (BAL)) [ 10].
In their sample, CPIS fell progressively in the population as a whole, and the decrease in CPIS was significant in survivors but not in non-survivors.
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