The first five issues won't be covered in proper sequence here, as they were printed from June through August 1915, and their anniversaries passed while I was abroad, searching for Ruhleben material at archives in London and at Leeds University.
There are seven SNPs covered in the sequence data for Inpp5f, with 2 of them shared by Inpp5f_v2.
When paternally- and maternally-expressed imprinted genes covered in the sequence read data are compared, we discovered an excess of paternal expression (11 paternal and 6 maternal), and most of these (9 of 11) show strong monoallelic expression (90% 100%).
The structure presented provides a structural explanation for all loss of activity mutations covered in the sequence, although this information was not used for model generation.
The input data to MutSigCV is lists of mutations (and indels) from a set of samples (patients) that were subjected to DNA sequencing, as well as information about how much of the genomic region is covered in the sequencing.
The sequencing results for both genomes were also analyzed for the type and size of homopolymers covered in the sequencing and summarized in Figures 1 and 2. The reference genome was then subdivided into bins of a specific number of bases, and the number of reads that started in each bin was recorded for every population.
It is feasible that additional de novo mutations could be present within regions of the genome not covered in our sequencing.
Deregulated protein kinase activity is frequently associated with, and members of the protein kinase family are commonly mutated in, cancer and are thus desired to be covered in cancer sequencing studies.
As we cannot rule out whether these sequences were not covered in the sequenced BAC clones or were not really conserved across the four genomes, they were not considered in the evolutionary relationship analysis.
For the difficulty in finding intron sources, another possibility is that exogenous sequences such as viruses have contributed sequences for most intron gains but have not yet been covered in any genome sequencing projects [ 15].
Comparisons between WGS scaffolds and these BAC sequences showed that 89.7% of the selected BAC sequences were covered in ungapped alignments, with average sequence identity of 99.93%.
