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Starting values are sampled with Latin Hypercube Sampling (LHS) [ 40] (see Additional file 1 supplementary text 2) for an efficient coverage of the sampled space.
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This increase in error could also be due to an insufficient coverage of the sampling area.
Design effects less than one indicate improvements in efficiency that may be due to the spatial coverage of the sample.
To improve representativeness and geographic coverage of the sample, no more than three households within the same apartment building were included.
In particular, one set of parameters can describe the behaviour of the magnetic field dependence for high and low oxygen coverage of the sample by changing only the parameters directly relevant to the energy transfer process.
After alkali treatment, the titanium plates with a surface roughness of Ra = 0.56 μm were completely covered with hydroxyapatite globules after 7 days in simulated body fluid (SBF), while the coverage of the samples with other surface roughness values remained incomplete.
The small number of multi domain hits found reflects the low coverage of the samples.
Repeating this procedure provided QTL profiles that were very similar (data not shown), indicating that the 100 repeats were adequate to achieve good coverage of the sample space.
The single Titanium run yielded 1,347,644 reads with an average length of 368 bases resulting in 495.5 million bases sequence information, which represents a 3.5-fold increase in coverage of the sample compared to the previous sequence dataset.
This suggests that the value of d should be chosen according to the coverage of the sample.
Major changes in copy number or sequencing efficiency were culled by filtering out signals stronger than 2.5 times the sequencing coverage of the sample.
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