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Sequence coverage of strain C. The number of mapped sequencing reads of Illumina analysis is plotted as a function of genome position.
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The benefit of the synergism would be not the antibiotic dose decrease but the coverage of strains with high MIC.
The average coverage of strains was 17x.
The recent identification of PI-2 in serotypes not covered by PCV7 has raised the possibility that broad coverage of strains can be achieved by a bivalent pilus-based vaccine.
The coverage of each strain was approximately 2.3x.
The ChIP coverage values of each histone mark shown in Fig. 2A were divided by the MNase coverage of each strain (in per-million reads, normalized by the size factor of the MNase sample, and averaged across replicates).
The most frequent discontinuous peptide has coverage of 754 strains, while the second most frequent peptide covers 320 strains.
Despite the difficulties in assembly encountered in virulent strains, the study was not negatively impacted since genomic coverage of these strains was still substantially high (> 84%) when aligned over the T2Bo_vir reference genome.
Briefly, the algorithm aims at selecting a given number of epitopes in a way so that the number of epitopes in the viral strain with fewest epitopes is as high as possible while simultaneously maximizing average coverage of all strains.
These vaccine designs compress HIV-1 diversity to maximize the coverage of circulating strains: the proposed inserts include the most common variants of HIV-1, thereby infecting strains will be more likely to match or be genetically closer to the vaccine antigen.
If vaccine-induced anti-FHbp antibodies have highest bactericidal activity against isolates from a modular group matching the vaccine strain(s) [ 31], our data would suggest that the multicomponent Novartis vaccine may provide better overall coverage of our strains.
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CEO of Professional Science Editing for Scientists @ prosciediting.com