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New infant infections are estimated from prevalence among pregnant women and the rate of mother-to-child transmission, which is dependent on infant feeding practices and the coverage of prophylaxis with ARVs.
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Weaknesses in facility record-keeping may have partly explained low coverage of ARV prophylaxis.
While the number of pregnant women with HIV continues to increase rapidly – reaching 3,430 in 2007, the coverage of medical prophylaxis for PMTCT has increased to over 92%.
If the fitness of the resistant strain is below 88%, a low coverage of antiviral prophylaxis can lead to a slightly smaller number of hospitalizations, whereas for larger fitness values, the expected number of hospitalizations grows with growing prophylaxis coverage.
Despite the above-mentioned limitations, the outcomes of this study provided real-life data on incidence and consequences of FN in these patient groups, and were subsequently submitted to the Belgian reimbursement commission as part of a request to extend the coverage of primary prophylaxis with pegfilgrastim.
One potential risk of our high levels of coverage is prophylaxis of younger patients.
The reported coverage of any antiretroviral (ARV) prophylaxis for prevention of mother-to-child transmission (PMTCT) has increased in sub-Saharan Africa in recent years, but was still only 60% in 2010.
Antibacterial prophylaxis should provide coverage of all likely pathogens, including aerobic and anaerobic organisms.
Although coverage of HIV testing, PMTCT and cotrimoxazole prophylaxis was high in all countries, decentralization of ART services was variable and incomplete.
Let's stop this pretence of prophylaxis.
Some form of prophylaxis was used in 205 patients (75%), including pharmacologic prophylaxis alone in 55 (20%), mechanical prophylaxis alone in 102 (38%), and both methods in 48 (18%).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com