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For the lower prevalence's (0.05 and 0.10) the coverage of approaches 4 and 6 was between 0.90 and 0.95 which were similar to those found by Mercaldo and colleagues themselves [ 12].
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The survey begins with a coverage of traditional approaches such as sequential routing and rip-up-and-reroute, and then discusses multicommodity flow-based methods, which have attracted a good deal of attention recently.
By using both the empirical Phase II HapMap CEU data (Utah residents with ancestry from northern and western Europe) [14] and the disease variants extracted from OMIM [15], we evaluated the coverage of the approaches in genic regions and the ability to capture disease variants in Caucasian population.
There is also the inevitable tension that spans the Atlantic Ocean, with less coverage of European approaches by the North American contributors, and a bias towards what is standard of care in parts of the USA.
Since our objective is to investigate the coverage of current approaches when dealing with the curation of existing databases, we can have more control on the false positives and false negatives.
Importantly, education in emergency medicine residency programs must ensure thorough coverage of the approach to the diagnosis and initial management of ischemic and hemorrhagic stroke syndromes.
Furthermore, development of a panel of genetic reference markers would allow broad population coverage of this approach.
The absence of subfamily J in GIII might be due to the insufficient coverage of our approach, or a lower fitness of this subfamily as suggested by its low presence also in Oregon-R.
Subfamilies C (with the exception of the 3'UTR fragment in GIII) and G would be an example of the opposite situation, the expression detected for these subfamilies is lower than expected for the genomic copies integrated in these genomes, nevertheless the differences in this case are subtle and could be explained by level of coverage of this approach.
This review article provides a coherent and comprehensive coverage of recently developed approaches and methods to tackle this problem.
We refer the reader to [37] for a good coverage of HPC-bound approaches for parallelising applications.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com