The estimated coverage of a process in currently available data was calculated as the average of rel(F, D) over all datasets in our study.
However, it inevitably causes sidewall scalloping roughness which may induce poor step coverage of following processes, resulting in electrical leakage and reliability issues.
The studies, in particular the ones based on LCA methods have provided comprehensive coverage of different processes such as energy consumption, manufacturing process and their impacts on the environments.
Due to the high density and wide coverage of immunoreactive processes, this approach generally reveals only minimal information about the morphologies of individual neurons.
The ongoing efforts on interrogating genetic and epigenetic functional elements (e.g., the ENCODE project [36]) will greatly enhance the available options for gene modules definition and improve the resolution, specificity and multi-faced coverage of biological processes.
To quantify the spatial coverage of microglial processes, we overlaid a grid on top of the skeletonized image (as illustrated in Fig. 4B) and calculated the total length of processes in each cell of the grid.
This was also reflected in the diversity of InterProScan categories identified (Additional file 1 Figure S6 and Figure S7), as well as the comprehensive coverage of biochemical processes by KEGG annotation, which was similar to that of the entire Arabidopsis gene catalog (Additional file 1 Figure S8).
This provides a global view of the functional structure of biological processes in yeast, including the degree of data-driven associations between processes, the experimental cohesiveness of gene behavior within each process, and the coverage of individual biological processes by currently available data.
Further research aims at measuring the performance of IAM processes [26] regarding their maturity level or quality and coverage of processes.
By computationally summarizing thousands of whole-genome experimental conditions, we elucidate the current data coverage of S.cerevisiae biological processes, the cohesiveness of its functional annotations, and associations among these processes based on high-throughput experimental results.
Moreover, the GO-annotation is potentially lagging behind on the current literature knowledge and has limited coverage of cardiac related processes and pathways.
